Endocrine Abstracts

The Endocrine Society guidelines define male hypogonadism as a ‘clinical syndrome’ where the diagnosis is based on symptoms or signs and unequivocally low serum testosterone (T) levels. Generally accepted by most clinicians, diagnosis of male hypogonadism is clinically relevant because T replacement can restore libido and correct sexual dysfunction, increase lean and decrease fat mass, increase in bone mineral density and vitality. Low serum T is associated wi...

Klinefelter syndrome (XXY males) is the most common sex chromosome aneuploidy, occurring in about 1 per 500 men. To study the underlying molecular mechanisms caused by the extra X chromosome, we have developed an experimental mouse model for men with Klinefelter’s syndrome. We have demonstrated that adult XXY mice have absence of germ cells, decreased serum testosterone levels, and elevated gonadotropin levels. Testicular failure begins early as a result of massive germ c...